To give another viewpoint, most of the campaigns I've run (or am working on for running soon) from RW have been AP based as well. I've built a lot of world background into the World Almanac however, then used the Story Almanac for the core content.
I've tried several different approaches though, and will no doubt try more:
Running Reign of Winter (mainly during Early Access), I followed a similar pattern to Shadow Chemosh, as I was having to play catchup as I was already halfway through the campaign. I used Quests for the different sections, with each room entered individually.
This worked fairly well, but it was slow swapping between rooms when they were close together.
For Rise of the Runelords and Shattered Star, I had a lot more time available to prepare in advance, so I've built both using the approach of building the world from top down - started with the planes, then solar system, then world, then built on down through Varisia to the actual area of the AP, all in the World Almanac, before switching to the Story Almanac.
The stories were set up using a single Storyline topic for each book, then a Quest topic for each chapter & sidequest, including the entire chapter's text in there, though NPCs and places of note had entries in the World Almanac.
Most of the room information went directly onto the map tags, other than creatures and treasure, which stayed in the Storyline topic, along with any text that couldn't fit into the map entries.
This resulted in a much quicker go-between, as I only had to have the map and chapter topic open most of the time, but some chapters did turn out to be somewhat overwhelming quantities of information. What this was very good for was viewing the information in a storyboard layout, and getting a good idea of the progression.
I'm still working on the World Almanac for my next campaign (Council of Thieves - the players have probably got a few months of the current campaign to go before that though), but I'm probably going to go for an approach somewhere between the above. My overall suggestion would be to play with things and find out what works best for you.