My system specs should make it SLIGHTLY faster than yours, but pretty similar. Running Hero Lab under Windows with 12 random monsters of CR 11 or higher, the response for me is extremely quick.
Switching between monsters via the dashboard takes less than 0.5 seconds.
Switching between the Spells and In-Play tab is essentially instantaneous.
I grabbed somewhat complex monsters for this test, centering on Demons and Devils due to their extensive powers and spell-like abilities.
So it definitely appears that WINE is the culprit here. I recommend grabbing VirtualBox, since it's free. Then you can run HL in demo mode within a VM to verify the performance issue is actually WINE without outlaying any extra cash for the test.
Hope this helps!
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