Ok the new guide is up.
Fame is gone
Your pathfinder Training School has changed, instead of different levels you pick one and that is it.
Faction boons you can purchase with fame are gone... for now... We should get clarity on that in a blog soon.
There might be other changes I am missing but those are the most relevant I could find for Hero Labs.
Hopefully a Blog will come out soon on what is happening to the Old stuff you bought with Fame and the Old Factions boons will come out soon.
http://www.organizedplayfoundation.o.../pfs2guide-en/