I use them for fully fleshed out encounters in systems that aren't supported by Hero Lab.
For example, I sometimes run a Custom Hunter game (think Supernatrual TV show) using the White Wolf nWoD rules. Hero Lab has nWoD for Mortals, Vampires, and Changelings, but nothing beyond that. I make custom creatures for each "episode", based on the TV show, Urban Legend, Lore, nWoD creatures, oWoD creatures, etc...
Hero Lab might work great for my RotRL campaign, but I need statblocks for everything else.
To keep things clean, I use statblocks, it's not in my face, unless I need it. a quick word file template does WONDERS for this, and while a simple text block would work (and which I use for easy npcs) the BBEG generally won't format nicely in a text block (not without weird line breaks happening from one resolution to another).
Just my 2 cents.
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