Because the book can be removed from your character once used, we don't want to put the activation on the book itself. I'd add "Ability Score (Permanent)" on the Permanent Adjustments table on the Personal tab, and in the "(source)" box, fill in "Manual of Gainful Exercise + 1". Then, if all the party members are using the same record keeping, you can flip to the Personal tab on each to see who could benefit from a new manual you're getting.
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