Something I've run into that I don't think RealmWorks handles very well right now are larger spaces which deserve more than a pin, instead encompassing some shape on the image.
Think something like the HTML map tag, but perhaps with nice semi-transparent colors or something similar (either always on or 'on mouseover').
Some use case examples:
* Playing a game set on Earth. I have a Smart Image map of the United States of America and I make a shape for the State of Texas which links to my RealmWorks Texas topic. I also could have pins for Austin, Houston, Dallas, etc.
* My players are in WaterDeep in Forgotten Realms. I'd like my smart image to display (and link to) the various wards (
http://forgottenrealms.wikia.com/wiki/Waterdeep#Layout )